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Literature summary for 3.2.2.31 extracted from
- Role of a MutY DNA glycosylase in combating oxidative DNA damage in Helicobacter pylori (2007), DNA Repair, 6, 19-26 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21 Rosetta pLys and PR70 cells | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | Helicobacter pylori | - |
? | - |
? |  |
| additional information | Helicobacter pylori | the enzyme shows no activity with DNA containing a guanine:adenine mismatch | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Helicobacter pylori |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | - |
Helicobacter pylori | ? | - |
? | |
| additional information | the enzyme shows no activity with DNA containing a guanine:adenine mismatch | Helicobacter pylori | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mutY | - |
Helicobacter pylori |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a significant role in oxidative DNA damage repair in vivo | Helicobacter pylori |
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