Protein Variants | Comment | Organism |
---|---|---|
K142A | the mutant shows slightly reduced activity compared to the wild type enzyme | Escherichia coli |
S120K | the mutant with bifunctional glycosylase/AP lyase activity is capable of catalyzing DNA strand scission at a rate equivalent to that of adenine excision for both guanine:adenine and 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair substrates | Escherichia coli |
S120K/K142A | the mutant with bifunctional glycosylase/AP lyase activity is capable of catalyzing DNA strand scission at a rate equivalent to that of adenine excision for both guanine:adenine and 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair substrates | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | Escherichia coli | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P17802 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | - |
Escherichia coli | ? | - |
? | |
DNA containing a guanine:adenine mismatch + H2O | - |
Escherichia coli | ? | - |
? | |
additional information | the enzyme has no activity with 2'-deoxyaristeromycin, 2'-deoxy-2'-fluoroadenosine, and 2'-deoxyformycin A | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mutY | - |
Escherichia coli |