Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.29 extracted from

  • Naydenova, E.; Dietschreit, J.C.B.; Ochsenfeld, C.
    Reaction mechanism for the N-glycosidic bond cleavage of 5-formylcytosine by thymine DNA glycosylase (2019), J. Phys. Chem. B, 123, 4173-4179 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
H151A the mutation results in a 2fold decrease in enzymatic activity Homo sapiens
N140A the mutation results in a decrease of enzymatic activity Homo sapiens
T197A the mutation results in a decrease of enzymatic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-fluoroarabino-5-formylcytidine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O Homo sapiens
-
thymine + double-stranded DNA with abasic site
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13569
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-formylcytosine-mismatched double-stranded DNA + H2O
-
Homo sapiens 5-formylcytosine + double-stranded DNA with abasic site
-
?
thymine-mismatched double-stranded DNA + H2O
-
Homo sapiens thymine + double-stranded DNA with abasic site
-
?

Synonyms

Synonyms Comment Organism
TDG
-
Homo sapiens
thymine DNA glycosylase
-
Homo sapiens