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Literature summary for 3.2.2.29 extracted from
- Mechanism of the glycosidic bond cleavage of mismatched thymine in human thymine DNA glycosylase revealed by classical molecular dynamics and quantum mechanical/molecular mechanical calculations (2015), J. Phys. Chem. B, 119, 12365-12380 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H151A | the mutant shows increased transition rates and activity compared to the wild type enzyme | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-fluoro-2'-deoxyuridine | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
5-carboxylcytosine + double-stranded DNA with abasic site | - |
? | |
| 5-formylcytosine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
5-formylcytosine + double-stranded DNA with abasic site | - |
? | |
| 5-hydroxymethyluridine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
5-hydroxymethyluridine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? | |
| uridine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
uridine + double-stranded DNA with abasic site | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13569 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-carboxylcytosine + double-stranded DNA with abasic site | - |
? | |
| 5-formylcytosine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-formylcytosine + double-stranded DNA with abasic site | - |
? | |
| 5-hydroxymethyluridine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-hydroxymethyluridine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
| uridine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | uridine + double-stranded DNA with abasic site | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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