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Literature summary for 3.2.2.29 extracted from
- Structural basis for excision of 5-formylcytosine by thymine DNA glycosylase (2016), Biochemistry, 55, 6205-6208 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| enzyme bound to DNA with a non-cleavable (2'-fluoroarabino) analog of 5-formyldeoxycytidine flipped into its active site | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13569 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-carboxylcytosine + double-stranded DNA with abasic site | - |
? | |
| 5-formylcytosine mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-formylcytosine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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