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Literature summary for 3.2.2.29 extracted from

  • Chen, C.; Zhou, D.; Tang, H.; Liang, M.; Jiang, J.
    A sensitive, homogeneous fluorescence assay for detection of thymine DNA glycosylase activity based on exonuclease-mediated amplification (2013), Chem. Commun. (Camb. ), 49, 5874-5876.
    View publication on PubMed
Search for more literature for 3.2.2.29

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O Homo sapiens
-
 thymine + double-stranded DNA with abasic site
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O
-
 Homo sapiens thymine + double-stranded DNA with abasic site
-
 ?

Synonyms

Synonyms Comment Organism
TDG
-
 Homo sapiens
thymine DNA glycosylase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays key roles in sustaining genome integrity because of its ability to selectively remove thymine from G/T mismatches through the DNA base excision repair pathway. The enzyme is actively involved in epigenetic regulation by participating in the DNA 5-methylcytosine demethylation processes Homo sapiens