KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000012 | - |
uracil-mismatched double-stranded DNA | excision of uracil from U/G mismatches | Homo sapiens | |
0.0000128 | - |
thymine-mismatched double-stranded DNA | excision of thymine from T/G mismatches | Homo sapiens | |
0.0000243 | - |
3,N4-ethenocytosine-mismatched double-stranded DNA | excision of 3,N4-ethenocytosine from 3,N4-ethenocytidine/G mismatches | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,N4-ethenocytosine-mismatched double-stranded DNA + H2O | Homo sapiens | 3,N4-ethenocytosine is recognized and efficiently excised by hTDG. The enzyme may be responsible for the repair of this mutagenic lesion in vivo and be important contributors to genetic stability | 3,N4-ethenocytosine + double-stranded DNA with abasic site | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13569 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,N4-ethenocytosine-mismatched double-stranded DNA + H2O | 3,N4-ethenocytosine is recognized and efficiently excised by hTDG. The enzyme may be responsible for the repair of this mutagenic lesion in vivo and be important contributors to genetic stability | Homo sapiens | 3,N4-ethenocytosine + double-stranded DNA with abasic site | - |
? | |
3,N4-ethenocytosine-mismatched double-stranded DNA + H2O | 3,N4-ethenocytosine is recognized and efficiently excised from the 3,N4-ethenocytosine/G duplex oligonucleotide, when this residue is situated opposite to G. 26.5% of the activity measured with 3,N4-ethenocytosine mismatches is observed with 3,N4-ethenocytosine/A mismatches, 71% with 3,N4-ethenocytosine/A mismatches | Homo sapiens | 3,N4-ethenocytosine + double-stranded DNA with abasic site | - |
? | |
thymine-mismatched double-stranded DNA + H2O | excision of thymine from T/G mismatches | Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
uracil-mismatched double-stranded DNA + H2O | excision of uracil from U/G mismatches | Homo sapiens | uracil + double-stranded DNA with abasic site | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hTDG | - |
Homo sapiens |
mismatch-specific thymine-DNA glycosylase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000015 | - |
thymine-mismatched double-stranded DNA | excision of thymine from T/G mismatches | Homo sapiens | |
0.000153 | - |
3,N4-ethenocytosine-mismatched double-stranded DNA | excision of 3,N4-ethenocytosine from 3,N4-ethenocytidine/G mismatches | Homo sapiens | |
0.00035 | - |
uracil-mismatched double-stranded DNA | excision of uracil from U/G mismatches | Homo sapiens |