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Literature summary for 3.2.2.29 extracted from

  • Yoon, J.H.; Iwai, S.; O'Connor, T.R.; Pfeifer, G.P.
    Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair (2003), Nucleic Acids Res., 31, 5399-5404.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.29

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine glycol-mismatched double-stranded DNA + H2O Homo sapiens oligonucleotides with thymine glycol incorporated into different sequence contexts and paired with adenine or guanine. TDG and methyl-CpG-binding protein 4 can remove thymine glycol when present opposite guanine but not when paired with adenine. The efficiency of these enzymes for removal of thymine glycol is about half of that for removal of thymine in the same sequence context. The two proteins may have evolved to act specifically on DNA mismatches produced by deamination and by oxidation-coupled deamination of 5-methylcytosine. This repair pathway contributes to mutation avoidance at methylated CpG dinucleotides thymine glycol + double-stranded DNA with abasic site
-
 ?
thymine-mismatched double-stranded DNA + H2O Homo sapiens oligonucleotides with thymine glycol incorporated into different sequence contexts and paired with adenine or guanine. TDG and methyl-CpG-binding protein 4 can remove thymine glycol when present opposite guanine but not when paired with adenine. The efficiency of these enzymes for removal of thymine glycol is about half of that for removal of thymine in the same sequence context. The two proteins may have evolved to act specifically on DNA mismatches produced by deamination and by oxidation-coupled deamination of 5-methylcytosine. This repair pathway contributes to mutation avoidance at methylated CpG dinucleotides thymine + double-stranded DNA with abasic site
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine glycol-mismatched double-stranded DNA + H2O oligonucleotides with thymine glycol incorporated into different sequence contexts and paired with adenine or guanine. TDG and methyl-CpG-binding protein 4 can remove thymine glycol when present opposite guanine but not when paired with adenine. The efficiency of these enzymes for removal of thymine glycol is about half of that for removal of thymine in the same sequence context. The two proteins may have evolved to act specifically on DNA mismatches produced by deamination and by oxidation-coupled deamination of 5-methylcytosine. This repair pathway contributes to mutation avoidance at methylated CpG dinucleotides Homo sapiens thymine glycol + double-stranded DNA with abasic site
-
 ?
thymine-mismatched double-stranded DNA + H2O oligonucleotides with thymine glycol incorporated into different sequence contexts and paired with adenine or guanine. TDG and methyl-CpG-binding protein 4 can remove thymine glycol when present opposite guanine but not when paired with adenine. The efficiency of these enzymes for removal of thymine glycol is about half of that for removal of thymine in the same sequence context. The two proteins may have evolved to act specifically on DNA mismatches produced by deamination and by oxidation-coupled deamination of 5-methylcytosine. This repair pathway contributes to mutation avoidance at methylated CpG dinucleotides Homo sapiens thymine + double-stranded DNA with abasic site
-
 ?

Synonyms

Synonyms Comment Organism
TDG
-
 Homo sapiens
thymine DNA glycosylase
-
 Homo sapiens