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Literature summary for 3.2.2.27 extracted from

  • Sarno, A.; Lundbaek, M.; Liabakk, N.B.; Aas, P.A.; Mjelle, R.; Hagen, L.; Sousa, M.M.L.; Krokan, H.E.; Kavli, B.
    Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil (2019), Nucleic Acids Res., 47, 4569-4585 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.27

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil-containing single-stranded DNA + H2O Mus musculus isoform UNG1, which in contrast to isoform UNG2 lacks a PCNA-binding motif, may be specialized to act on single stranded DNA (ssDNA) through its ability to bind ssDNA-binding protein RPA uracil + single-stranded DNA with abasic site
-
 ?
uracil-containing single-stranded DNA + H2O Homo sapiens isoform UNG1, which in contrast to isoform UNG2 lacks a PCNA-binding motif, may be specialized to act on single stranded DNA (ssDNA) through its ability to bind ssDNA-binding protein RPA uracil + single-stranded DNA with abasic site
-
 ?
uracil-mismatched double-stranded DNA + H2O Mus musculus
-
 uracil + double-stranded DNA with abasic site
-
 ?
uracil-mismatched double-stranded DNA + H2O Homo sapiens
-
 uracil + double-stranded DNA with abasic site
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P13051
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
 Mus musculus
-
CH-12F3 cell
-
 Mus musculus
-
CMT-93 cell
-
 Mus musculus
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
JC cell
-
 Mus musculus
-
L-428 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Mus musculus
-
U-373 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUMP-labeled calf thymus DNA + H2O
-
 Mus musculus uracil + ?
-
 ?
dUMP-labeled calf thymus DNA + H2O
-
 Homo sapiens uracil + ?
-
 ?
M6-FAM-labeled single stranded oligonucleotide + H2O T12-AGUA-T12 Mus musculus uracil + ?
-
 ?
M6-FAM-labeled single stranded oligonucleotide + H2O T12-AGUA-T12 Homo sapiens uracil + ?
-
 ?
uracil-containing single-stranded DNA + H2O isoform UNG1, which in contrast to isoform UNG2 lacks a PCNA-binding motif, may be specialized to act on single stranded DNA (ssDNA) through its ability to bind ssDNA-binding protein RPA Mus musculus uracil + single-stranded DNA with abasic site
-
 ?
uracil-containing single-stranded DNA + H2O isoform UNG1, which in contrast to isoform UNG2 lacks a PCNA-binding motif, may be specialized to act on single stranded DNA (ssDNA) through its ability to bind ssDNA-binding protein RPA Homo sapiens uracil + single-stranded DNA with abasic site
-
 ?
uracil-mismatched double-stranded DNA + H2O
-
 Mus musculus uracil + double-stranded DNA with abasic site
-
 ?
uracil-mismatched double-stranded DNA + H2O
-
 Homo sapiens uracil + double-stranded DNA with abasic site
-
 ?

Subunits

Subunits Comment Organism
? x * 30000, isoform UNG1, SDS-PAGE Mus musculus
? x * 30000, isoform UNG1, SDS-PAGE Homo sapiens
? x * 36000, isoform UNG2, SDS-PAGE Mus musculus
? x * 36000, isoform UNG2, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UNG1 isoform Mus musculus
UNG1 isoform Homo sapiens
UNG2 isoform Mus musculus
UNG2 isoform Homo sapiens

General Information

General Information Comment Organism
physiological function isoform UNG1 supports antibody class switching and repairs genomic uracil in the cell nucleus Mus musculus
physiological function isoform UNG1 supports antibody class switching and repairs genomic uracil in the cell nucleus Homo sapiens