Cloned (Comment) | Organism |
---|---|
genes udgB and ung, phylogenetic analysis | Mycolicibacterium smegmatis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of udgB and ung knockout mutants by allelic replacement techniques. The general mutation frequency is increased in UDG knockout strains, frequencies of A:T to G:C mutations, which may arise through adenine deamination, in the udgB knockout mutant and in the double-knockout mutant are 10fold and 31fold higher that those in the wild-type strain, respectively, overview | Mycolicibacterium smegmatis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | association of Ung with the replication fork | Mycolicibacterium smegmatis | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mycolicibacterium smegmatis | UdgB removes aberrant bases uracil, from deaminated cytosine, and hypoxanthine, from deaminated adenine, and 5-fluorouracil from DNA with high efficiency | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycolicibacterium smegmatis | - |
genes udgB and ung | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UdgB removes aberrant bases uracil, from deaminated cytosine, and hypoxanthine, from deaminated adenine, and 5-fluorouracil from DNA with high efficiency | Mycolicibacterium smegmatis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UdgB | - |
Mycolicibacterium smegmatis |
Ung-type uracil glycosylase | - |
Mycolicibacterium smegmatis |
uracil DNA glycosylase | - |
Mycolicibacterium smegmatis |
General Information | Comment | Organism |
---|---|---|
malfunction | thymidylate synthase inhibition leads to UDG-dependent cell death | Mycolicibacterium smegmatis |
physiological function | UdgB from Mycobacterium smegmatis protects this organism against mutagenesis associated with deamination of both cytosine and adenine. Together with Ung-type uracil glycosylase, UdgB also helps attenuate the cytotoxicity of the antimicrobial agent 5-fluorouracil | Mycolicibacterium smegmatis |