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Literature summary for 3.2.2.27 extracted from

  • Guo, C.; Zhang, X.; Fink, S.P.; Platzer, P.; Wilson, K.; Willson, J.K.; Wang, Z.; Markowitz, S.D.
    Ugene, a newly identified protein that is commonly overexpressed in cancer, and that binds uracil DNA-glycosylase (2008), Cancer Res., 68, 6118-6126.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.27

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-Myc-tagged GFP-fusion UNG2 1-25 in DLD1 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus UNG2 is a constitutive enzyme in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UNG2 is an important enzyme in the base excision repair pathway, interaction with Ugene is involved in the phenotype of colon cancer, Ugene interacts with the base excision repair pathway, overview ?
-
 ?
uracil-mismatched double-stranded DNA + H2O Homo sapiens
-
 uracil + double-stranded DNA with abasic site
-
 ?
uracil-mismatched single-stranded DNA + H2O Homo sapiens
-
 uracil + single-stranded DNA with abasic site
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22674
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell primary cells from liver and colon Homo sapiens
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colon
-
 Homo sapiens
-
DLD-1 cell colorectal carcinoma cell line Homo sapiens
-
liver
-
 Homo sapiens
-
SW-480 cell colon adenocarcinoma cell line Homo sapiens
-
VACO cell colon tumor cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UNG2 is an important enzyme in the base excision repair pathway, interaction with Ugene is involved in the phenotype of colon cancer, Ugene interacts with the base excision repair pathway, overview Homo sapiens ?
-
 ?
additional information specific excision and removal of dUTP from dsDNA and ssDNA, cleavage of for U-A and U-G pairs. UNG2 binds to Ugene, a nuclear protein overexpressed in colon cancer, Ugene-p binds to the NH2-terminus of UNG2, which does not directly alter UNG2 enzymatic activity or localization, interaction analysis, overview Homo sapiens ?
-
 ?
uracil-mismatched double-stranded DNA + H2O
-
 Homo sapiens uracil + double-stranded DNA with abasic site
-
 ?
uracil-mismatched single-stranded DNA + H2O
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 Homo sapiens uracil + single-stranded DNA with abasic site
-
 ?

Synonyms

Synonyms Comment Organism
UNG2
-
 Homo sapiens
uracil DNA-glycosylase
-
 Homo sapiens
uracil DNA-glycosylase 2
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 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens