Cloned (Comment) | Organism |
---|---|
expression of EGFP-tagged enzyme in HEK-293T cells. Transformation of primary human fibroblasts of a Cockayne syndrome patient using SV40, expression of FPG in 5-hydroxy-2'-deoxycytidine repair defective human cells complements the disorder and leads to stable correction of the delayed removal of both oxidized purines and oxidized pyrimidines in the cells, detailed overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,6-diamino-4-hydroxy-5-formamidopyrimidine:Cyt oligodeoxynucleotide + H2O | Escherichia coli | - |
2,6-diamino-4-hydroxy-5-formamidopyrimidine + Cyt oligodeoxynucleotide | - |
? | |
8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O | Escherichia coli | - |
8-oxo-7,8-dihydroguanine + Cyt oligodeoxynucleotide | - |
? | |
additional information | Escherichia coli | defective repair of 5-hydroxy-2-deoxycytidine in Cockayne syndrome cells is complementated by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,6-diamino-4-hydroxy-5-formamidopyrimidine:Cyt oligodeoxynucleotide + H2O | - |
Escherichia coli | 2,6-diamino-4-hydroxy-5-formamidopyrimidine + Cyt oligodeoxynucleotide | - |
? | |
8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O | - |
Escherichia coli | 8-oxo-7,8-dihydroguanine + Cyt oligodeoxynucleotide | - |
? | |
additional information | defective repair of 5-hydroxy-2-deoxycytidine in Cockayne syndrome cells is complementated by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
formamidopyrimidine DNA glycosylase | - |
Escherichia coli |
FPG | - |
Escherichia coli |