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Literature summary for 3.2.2.23 extracted from

  • Krishnamurthy, N.; Muller, J.G.; Burrows, C.J.; David, S.S.
    Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg (2007), Biochemistry, 46, 9355-9365.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
E3Q inactive. Mutant binds DNA duplexes containing spiroiminodihydantoin or guanidinohydantoin about 1000fold more tightly over corresponding duplexes containing 8-oxoguanine Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli enzyme mediates repair of lesions containing hydantoins in vivo ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing guanidinohydantoin + H2O for DNA duplex length of 30 bp, the excision efficiency in pairs with C, G, or T is similar to 8-oxoguanine. Opposite A, the base removal activity is more efficient than removal of 8-oxoguanine Escherichia coli guanidinohydantoin + DNA
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 ?
DNA containing spiroiminodihydantoin + H2O for DNA duplex length of 30 bp, the excision efficiency in pairs with C, G, or T is similar to 8-oxoguanine. Opposite A, the base removal activity is more efficient than removal of 8-oxoguanine Escherichia coli spiroiminodihydantoin + DNA
-
 ?
additional information enzyme mediates repair of lesions containing hydantoins in vivo Escherichia coli ?
-
 ?