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Literature summary for 3.2.2.23 extracted from
- New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase (1994), J. Biol. Chem., 269, 18814-18820.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | Escherichia coli | biological substrates are purine oxidation products | ? | - |
? |  |
| DNA + H2O | Escherichia coli | DNA base excision repair enzyme | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine | mechanism | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | biological substrates are purine oxidation products | Escherichia coli | ? | - |
? | |
| DNA + H2O | DNA base excision repair enzyme | Escherichia coli | ? | - |
? | |
| DNA containing 5-hydroxy-2'-deoxyuridine + H2O | double-stranded oligonucleotides, N-glycosylase/beta,delta-elimination reaction | Escherichia coli | ? | - |
? | |
| DNA containing 5-hydroxycytosine residues + H2O | double-stranded oligonucleotides containing 5-hydroxy-2'-deoxycytidine, N-glycosylase/beta,delta-elimination reaction | Escherichia coli | ? | - |
? | |
| DNA containing 7-hydro-8-oxoguanine residues + H2O | - |
Escherichia coli | DNA + 7-hydro-8-oxoguanine | - |
? | |
| DNA containing ring-opened N7-methylguanine residues + H2O | - |
Escherichia coli | 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine + DNA | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Escherichia coli |
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Release 2023.1 (January 2023)
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