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Literature summary for 3.2.2.23 extracted from

  • Tchou, J.; Bodepudi, V.; Shibutani, S.; Antoshechkin, I.; Miller, J.; Grollman, A.P.; Johnson, F.
    Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA (1994), J. Biol. Chem., 269, 15318-15324.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic parameters of duplex oligonucleotides and mismatched duplexes Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 7-hydro-8-oxoguanine + H2O Escherichia coli repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA 7-hydro-8-oxoguanine + DNA
-
?
DNA containing ring-opened N7-methylguanine + H2O Escherichia coli repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine + DNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine catalytic mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O substrate specificity Escherichia coli ?
-
?
DNA + H2O enzyme has N-glycosylase and apurinic/apyrimidinic lyase activity Escherichia coli ?
-
?
DNA containing 7-hydro-8-oxoguanine + H2O repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA Escherichia coli 7-hydro-8-oxoguanine + DNA
-
?
DNA containing 7-hydro-8-oxoguanine residues + H2O the C-8 keto group of 8-oxodeoxyguanine and the carbonyl moiety of formamidopyrimidine enable the enzyme to recognize and bind duplex DNA containing modified bases Escherichia coli DNA + 7-hydro-8-oxoguanine
-
?
DNA containing 7-hydro-8-oxoguanine residues + H2O mechanism involving protonation at O-6 of 8-oxodeoxyguanine Escherichia coli DNA + 7-hydro-8-oxoguanine
-
?
DNA containing 8-oxo-2'-deoxyinosine + H2O dublex Escherichia coli ?
-
?
DNA containing ring-opened N7-methylguanine + H2O repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA Escherichia coli 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine + DNA
-
?
DNA containing ring-opened N7-methylguanine residues + H2O the C-8 keto group of 8-oxodeoxyguanine and the carbonyl moiety of formamidopyrimidine enable the enzyme to recognize and bind duplex DNA containing modified bases, mechanism Escherichia coli 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine + DNA
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information turnover of duplex oligonucleotides and mismatched duplexes Escherichia coli