KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic parameters of duplex oligonucleotides and mismatched duplexes | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 7-hydro-8-oxoguanine + H2O | Escherichia coli | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | 7-hydro-8-oxoguanine + DNA | - |
? | |
DNA containing ring-opened N7-methylguanine + H2O | Escherichia coli | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine + DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine | catalytic mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + H2O | substrate specificity | Escherichia coli | ? | - |
? | |
DNA + H2O | enzyme has N-glycosylase and apurinic/apyrimidinic lyase activity | Escherichia coli | ? | - |
? | |
DNA containing 7-hydro-8-oxoguanine + H2O | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | Escherichia coli | 7-hydro-8-oxoguanine + DNA | - |
? | |
DNA containing 7-hydro-8-oxoguanine residues + H2O | the C-8 keto group of 8-oxodeoxyguanine and the carbonyl moiety of formamidopyrimidine enable the enzyme to recognize and bind duplex DNA containing modified bases | Escherichia coli | DNA + 7-hydro-8-oxoguanine | - |
? | |
DNA containing 7-hydro-8-oxoguanine residues + H2O | mechanism involving protonation at O-6 of 8-oxodeoxyguanine | Escherichia coli | DNA + 7-hydro-8-oxoguanine | - |
? | |
DNA containing 8-oxo-2'-deoxyinosine + H2O | dublex | Escherichia coli | ? | - |
? | |
DNA containing ring-opened N7-methylguanine + H2O | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | Escherichia coli | 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine + DNA | - |
? | |
DNA containing ring-opened N7-methylguanine residues + H2O | the C-8 keto group of 8-oxodeoxyguanine and the carbonyl moiety of formamidopyrimidine enable the enzyme to recognize and bind duplex DNA containing modified bases, mechanism | Escherichia coli | 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine + DNA | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | turnover of duplex oligonucleotides and mismatched duplexes | Escherichia coli |