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Literature summary for 3.2.2.22 extracted from
- Research on ribosome-inactivating proteins from angiospermae to gymnospermae and cryptogamia (2017), Am. J. Transl. Res., 9, 5719-5742 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cinnamomum camphora | Q94BW3 | - |
- |
| Platycladus orientalis | - |
i.e. Biota orientalis | - |
| Saccharina japonica | - |
- |
- |
| Trichosanthes kirilowii | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Cinnamomum camphora |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Platycladus orientalis | - |
| seed | - |
Saccharina japonica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| rat 28S rRNA + H2O | - |
Platycladus orientalis | ? | - |
? |  |
| rat 28S rRNA + H2O | - |
Saccharina japonica | ? | - |
? | |
| rat 28S rRNA + H2O | - |
Trichosanthes kirilowii | ? | - |
? | |
| rat 28S rRNA + H2O | - |
Cinnamomum camphora | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 27000, SDS-PAGE | Trichosanthes kirilowii |
| ? | x * 61000, SDS-PAGE | Cinnamomum camphora |
| ? | x * 36000, SDS-PAGE | Saccharina japonica |
| ? | x * 13000, SDS-PAGE | Platycladus orientalis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cinnamomin | - |
Cinnamomum camphora |
| lamjapin | - |
Saccharina japonica |
| RNase Bo | - |
Platycladus orientalis |
| trichosanthin | - |
Trichosanthes kirilowii |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 100 | - |
10 min, stable | Platycladus orientalis |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Saccharina japonica | isoelectric focusing | - |
8.4 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | cinnamomin potently inhibits the in vitro protein synthesis in the rabbit reticulocyte lysate system or a reconstituted protein synthesis system composed of rat ribosome with IC50 value of about 9.7 nM. The cleavage of supercoiled double-stranded DNA is an intrinsic property of cinnamomin A-chain, its N- and C-terminal regions are required for deadenylation of rRNA and also necessary for deadenylation of supercoiled double-stranded circular DNA | Cinnamomum camphora |
| physiological function | lamjapin inhibits protein synthesis in the cell-free system of rabbit reticulocyte with an IC50 value of about 0.03-4 nM | Saccharina japonica |
| physiological function | trichosanthin is highly toxic to trophoblasts and choriocarcinoma cells. Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2-choriocarcinoma cell lines | Trichosanthes kirilowii |
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Release 2023.1 (January 2023)
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