Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli 98NK2 (O113:H21) | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
28S rRNA + H2O | - |
Escherichia coli | ? | - |
? | |
28S rRNA + H2O | - |
Escherichia coli 98NK2 (O113:H21) | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ribosome inactivating protein | - |
Escherichia coli |
RIP | - |
Escherichia coli |
Shiga toxin 2 | - |
Escherichia coli |
Stx2 | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | Shiga toxins (Stx) expressed in the intestinal lumen during infection with Shiga-toxigenic Escherichia coli must translocate across the epithelium and enter the systemic circulation to cause systemic (pathological) effects, including hemolytic uremic syndrome. Even though Stxs are potent protein synthesis inhibitors, both isoforms Stx1 and Stx2 have been shown to upregulate interleukin-8 protein expression in intestinal epithelial cells via the ribotoxic stress response, a signal transduction event resulting from specific damage to the 28S rRNA that causes activation of host stress-activated protein kinases. Stx1 and Stx2 are also capable of inducing MAPK activation in vitro | Escherichia coli |