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Literature summary for 3.2.2.22 extracted from

  • Pruet, J.M.; Jasheway, K.R.; Manzano, L.A.; Bai, Y.; Anslyn, E.V.; Robertus, J.D.
    7-Substituted pterins provide a new direction for ricin A chain inhibitors (2011), Eur. J. Med. Chem., 46, 3608-3615.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.22

Crystallization (Commentary)

Crystallization (Comment) Organism
ricin A chain in complex with inhibitor 7-carboxy pterin, hanging drop vapor diffusion method, using 75 mM Tris-HCl pH 8.9, 10 mM BME, 1 mM EDTA, 4.1% (w/v) PEG MW 8000 Ricinus communis

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-oxo-3,4-dihydro-pteridine 7-carbohydrazide 35% inhibition at 0.5 mM Ricinus communis
7-acetylpterin 20% inhibition at 0.5 mM Ricinus communis
7-carboxypterin
-
 Ricinus communis
7-propionylpterin
-
 Ricinus communis
additional information not inhibited by 7-carbamoylpterin, N-(3,4,5-trimethoxybenzyl)-7-carbamoylpterin, and 7-(p-methoxybenzoyl)pterin Ricinus communis
N-(2-(phenylamino) ethyl)-7-carbamoylpterin
-
 Ricinus communis
N-(4-fluorobenzyl)-7-carbamoylpterin
-
 Ricinus communis
N-(furanylmethyl)-7-carbamoylpterin
-
 Ricinus communis
N-(methylamino pyridinyl)-7-carbamoylpterin
-
 Ricinus communis
N-methyl-7-carbamoylpterin
-
 Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
 Ricinus communis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
rRNA + H2O
-
 Ricinus communis ?
-
 ?

Synonyms

Synonyms Comment Organism
ricin
-
 Ricinus communis
RIP
-
 Ricinus communis
RTA ricin A chain Ricinus communis
type 2 ribosome inactivating protein
-
 Ricinus communis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.2
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis 7-carboxypterin
0.2
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis N-(2-(phenylamino) ethyl)-7-carbamoylpterin
0.4
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis N-(furanylmethyl)-7-carbamoylpterin
0.5
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis N-(methylamino pyridinyl)-7-carbamoylpterin
0.6
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis N-(4-fluorobenzyl)-7-carbamoylpterin
0.7
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis 7-propionylpterin
1.6
-
 in 100 mM HEPES pH 7.5, 125 mM NaCl, at 25°C Ricinus communis N-methyl-7-carbamoylpterin