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Literature summary for 3.2.2.22 extracted from

  • Wahome, P.G.; Bai, Y.; Neal, L.M.; Robertus, J.D.; Mantis, N.J.
    Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen (2010), Toxicon, 56, 313-323.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.22

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-(5-methylfuran-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)prop-2-enamide CID 16271106, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic Ricinus communis
2-methylsulfonyl-1-(naphthalen-1-ylmethyl)benzimidazole CID 18576762, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic Ricinus communis
4,6-bis(propan-2-ylamino)-1,3,5-triazine-2-carbonitrile CID 644401, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic Ricinus communis
brefeldin A shows significant anti-ricin activity Ricinus communis
gliotoxin shows significant anti-ricin activity Ricinus communis
methyl 2-[(5E)-5-[[5-(azepan-1-yl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate CID 5737931, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic Ricinus communis
additional information group I small-molecule compounds demonstrate relatively low ricin inhibitory activity and cytotoxicity, group II small-molecules consists of compounds that show relatively high ricin inhibitory activity at low concentrations, but high cytotoxicity Ricinus communis
N-cyclohexyl-N-[(4-fluorophenyl)methyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide CID 7531223 Ricinus communis
Thiostrepton shows significant anti-ricin activity Ricinus communis
TPCK shows significant anti-ricin activity Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis P02879
-
-

Synonyms

Synonyms Comment Organism
ricin
-
 Ricinus communis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.25
-
-
 Ricinus communis N-cyclohexyl-N-[(4-fluorophenyl)methyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide