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Literature summary for 3.2.2.22 extracted from
- Anti-tumor activity and immunological modification of ribosome-inactivating protein (RIP) from Momordica charantia by covalent attachment of polyethylene glycol (2009), Acta Biochim. Biophys. Sin. (Shanghai), 41, 792-799.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of enzyme-PEG conjugates and immunogenicity analysis, overview. RIP-PEG conjugates show a strong anti-tumor activity through apoptotic pathway like RIP, buts with less toxicity to normal cells and reduced antigenicity | Momordica charantia |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
x * 30000, SDS-PAGE | Momordica charantia |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Momordica charantia | ribosome-inactivating proteins, RIPs, are a family of enzymes that depurinate rRNA and inhibit protein biosynthesis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Momordica charantia | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from seeds by ammonium sulfate fractionation, and two steps of gel filtration | Momordica charantia |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Momordica charantia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | ribosome-inactivating proteins, RIPs, are a family of enzymes that depurinate rRNA and inhibit protein biosynthesis | Momordica charantia | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 30000, SDS-PAGE | Momordica charantia |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ribosome-inactivating protein | - |
Momordica charantia |
| RIP | - |
Momordica charantia |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Momordica charantia | isoelectric focusing | - |
9 |
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Release 2023.1 (January 2023)
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