Literature summary for 3.2.2.22 extracted from

Munoz, R.; Arias, Y.; Ferreras, J.M.; Rojo, M.A.; Gayoso, M.J.; Nocito, M.; Benitez, J.; Jimenez, P.; Bernabeu, C.; Girbes, T.
Targeting a marker of the tumour neovasculature using a novel anti-human CD105-immunotoxin containing the non-toxic type 2 ribosome-inactivating protein nigrin b (2007), Cancer Lett., 256, 73-80.

Search for more literature for 3.2.2.22

Application

Application	Comment	Organism
medicine	construction of a immunotoxin consisting of the non-toxic type 2 ribosome-inactivating protein nigrin b linked to the monoclonal anti-human CD105 antibody 44G4. The immunotoxin kills specifically mouse fibroblasts expressing the biomarker CD105 with an IC50 value of 0.6 nM while nigrin does it at 0.24 microM. The immunotoxin accumulates in a perinuclear region	Sambucus nigra

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a immunotoxin consisting of the non-toxic type 2 ribosome-inactivating protein nigrin b linked to the monoclonal anti-human CD105 antibody 44G4. The immunotoxin kills specifically mouse fibroblasts expressing the biomarker CD105 with an IC50 value of 0.6 nM while nigrin does it at 0.24 microM	Sambucus nigra

Organism

Organism	UniProt	Comment	Textmining
Sambucus nigra	-	isoform nigrin B	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)