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Literature summary for 3.2.2.22 extracted from

  • Hess, P.R.; Barnes, C.; Woolard, M.D.; Johnson, M.D.; Cullen, J.M.; Collins, E.J.; Frelinger, J.A.
    Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin (2007), Blood, 109, 3300-3307.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine major histocompatibility complex class I tetramers H2-Db assembled using streptavidin conjugated to the ribosome-inactivating protein saporin. These tetramers inhibit ribosome activity in vitro, retain the T-cell receptor-binding specificity of their nontoxic counterparts, and are internalized by 100% of target cells, leading to cell death in 72 hours. Cytotoxicity is dependent on the tetramer dose and avidity for the T cell Saponaria officinalis

Protein Variants

Protein Variants Comment Organism
additional information major histocompatibility complex class I tetramers H2-Db assembled using streptavidin conjugated to the ribosome-inactivating protein saporin. These tetramers inhibit ribosome activity in vitro, retain the T-cell receptor-binding specificity of their nontoxic counterparts, and are internalized by 100% of target cells, leading to cell death in 72 hours. Cytotoxicity is dependent on the tetramer dose and avidity for the T cell Saponaria officinalis

Organism

Organism UniProt Comment Textmining
Saponaria officinalis
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