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Literature summary for 3.2.2.22 extracted from

  • Gasperi-Campani, A.; Brognara, I.; Baiocchi, D.; Roncuzzi, L.
    Mitochondrial DNA D-loop as a new target of saporin 6 nuclease activity (2005), Toxicon, 45, 475-480.
    View publication on PubMed
Search for more literature for 3.2.2.22

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
rRNA + H2O Saponaria officinalis PAP causes translation arrest and is cytotoxic in targeted eukaryotic cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saponaria officinalis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human mtDNA + H2O saporin 6 shows specific nuclease activity towards the D-loop of human mitochondrial, covalently closed circular DNA, determination of sites of action by restriction analysis Saponaria officinalis ?
-
 ?
rRNA + H2O PAP causes translation arrest and is cytotoxic in targeted eukaryotic cells Saponaria officinalis ?
-
 ?
rRNA + H2O the ribotoxin depurinates a specific adenine in the highly conserved alpha-sarcin loop of the large subunit rRNA of eukaryotic ribosomes Saponaria officinalis ?
-
 ?

Synonyms

Synonyms Comment Organism
saporin 6
-
 Saponaria officinalis
single-chain ribosome-inactivating protein
-
 Saponaria officinalis
type I ribosome-inactivating protein
-
 Saponaria officinalis
type I RIP
-
 Saponaria officinalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
21 37 activity range, nuclease activity on mtDNA Saponaria officinalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.8 nuclease activity on mtDNA Saponaria officinalis