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Literature summary for 3.2.2.22 extracted from

  • Sestili, P.; Alfieri, R.; Carnicelli, D.; Martinelli, C.; Barbieri, L.; Stirpe, F.; Bonelli, M.; Petronini, P.G.; Brigotti, M.
    Shiga toxin 1 and ricin inhibit the repair of H2O2-induced DNA single strand breaks in cultured mammalian cells (2005), DNA Repair, 4, 271-277.
    View publication on PubMed
Search for more literature for 3.2.2.22

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ricinus communis the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview ?
-
 ?
additional information Shigella dysenteriae the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Ricinus communis
-
-
-
Shigella dysenteriae
-
 isozyme Stx1
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from seeds Ricinus communis
recombinant Stx1 expressed in Escherichia coli Shigella dysenteriae

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
 Ricinus communis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Ricinus communis
additional information
-
-
 Shigella dysenteriae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview Ricinus communis ?
-
 ?
additional information the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview Shigella dysenteriae ?
-
 ?

Subunits

Subunits Comment Organism
dimer heterodimer formed by a catalytic subunit A and a carbohydrate binding subunit B Shigella dysenteriae
dimer heterodimer formed by a catalytic subunit A, RTA, and a carbohydrate binding subunit B, RTB Ricinus communis

Synonyms

Synonyms Comment Organism
ricin
-
 Ricinus communis
Shiga toxin 1
-
 Shigella dysenteriae
Stx1
-
 Shigella dysenteriae
type II ribosome-inactivating protein
-
 Ricinus communis
type II ribosome-inactivating protein
-
 Shigella dysenteriae
type II RIP
-
 Ricinus communis
type II RIP
-
 Shigella dysenteriae