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Literature summary for 3.2.2.22 extracted from

  • Tomatsu, M.; Kondo, T.; Yoshikawa, T.; Komeno, T.; Adachi, N.; Kawasaki, Y.; Ikuta, A.; Tashiro, F.
    An apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata (2004), Biol. Chem., 385, 819-827.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information the cytotoxic enzyme induces apoptosis in transformed cells Aralia elata

Inhibitors

Inhibitors Comment Organism Structure
fucose glucose, mannose, and N-acetylglucosamine show poor inhibitory effects Aralia elata
galactose and derivatives, inhibits the incorporation of the enzyme into target cells via its cell surface receptor, and inhibits the inhibition of protein synthesis through the enzyme, minimum inhibition concentration is 3.3 mM Aralia elata
lactose minimum inhibition concentration is 0.8 mM Aralia elata
melibiose minimum inhibition concentration is 1.0 mM Aralia elata
N-acetylgalactosamine minimum inhibition concentration is 4.2 mM Aralia elata

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme enters target cells via its cell surface receptor Aralia elata
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
1 * 29000, A-chain, + 1 * 32000, B-chain, SDS-PAGE Aralia elata
32000
-
1 * 29000, A-chain, + 1 * 32000, B-chain, SDS-PAGE Aralia elata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Aralia elata the cytotoxic enzyme induces apoptosis in transformed cells by inhibiting protein synthesis and inactivating ribosomes, the enzyme targets diverse cells, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Aralia elata
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Aralia elata

Purification (Commentary)

Purification (Comment) Organism
native enzyme 611.4fold from shoots by ammonium sulfate fractionation, ion exchange chromatography and gel filtration Aralia elata

Source Tissue

Source Tissue Comment Organism Textmining
shoot
-
Aralia elata
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
cytotoxic effects on WI-38 and VA-13 cells Aralia elata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
28S rRNA + H2O substrate from rat liver ribosomes, generation of an R-fragment from 28S RNA, product determination using aniline coupling Aralia elata ?
-
?
additional information the cytotoxic enzyme induces apoptosis in transformed cells by inhibiting protein synthesis and inactivating ribosomes, the enzyme targets diverse cells, overview Aralia elata ?
-
?
additional information the enzyme targets diverse cells, e.g. WI-38 cells or VA-13 cells, overview Aralia elata ?
-
?

Subunits

Subunits Comment Organism
dimer 1 * 29000, A-chain, + 1 * 32000, B-chain, SDS-PAGE Aralia elata

Synonyms

Synonyms Comment Organism
aralin
-
Aralia elata
RIP
-
Aralia elata
RNA N-glycosidase
-
Aralia elata
type II ribosome-inactivating protein
-
Aralia elata