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Literature summary for 3.2.2.22 extracted from

  • Yamasaki, C.; Nishikawa, K.; Zeng, X.T.; Katayama, Y.; Natori, Y.; Komatsu, N.; Oda, T.
    Induction of cytokines by toxins that have an identical RNA N-glycosidase activity: Shiga toxin, ricin, and modeccin (2004), Biochim. Biophys. Acta, 1671, 44-50.
    View publication on PubMed
Search for more literature for 3.2.2.22

Protein Variants

Protein Variants Comment Organism
additional information a GST-tagged chimeric pentameric mutant enzyme comprising parts of ricin and of Shiga toxin shows no RNA N-glycosidase activity Ricinus communis
additional information a GST-tagged chimeric pentameric mutant enzyme comprising parts of ricin and of Shiga toxin shows no RNA N-glycosidase activity Shigella dysenteriae

Inhibitors

Inhibitors Comment Organism Structure
brefeldin A inhibits interleukin-8 induction by the enzymethrough inhibition of the toxin transport from Golgi to the cytosol, overview Ricinus communis
brefeldin A inhibits interleukin-8 induction by the enzyme through inhibition of the toxin transport from Golgi to the cytosol, overview Shigella dysenteriae
Gb3-liposomes inhibition of cell toxicity Shigella dysenteriae
lactose inhibition of cell toxicity Ricinus communis
additional information no inhibition of cell toxicity by Gb4- and Gb3-liposomes, and sucrose Ricinus communis
additional information no inhibition of cell toxicity by Gb4-liposomes, lactose, and sucrose Shigella dysenteriae

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme enters target cells via its cell surface receptor Ricinus communis
-
-
extracellular the enzyme enters target cells via its cell surface receptor Corynebacterium diphtheriae
-
-
extracellular the enzyme enters target cells via its cell surface receptor Shigella dysenteriae
-
-
extracellular the enzyme enters target cells via its cell surface receptor Adenia digitata
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Corynebacterium diphtheriae the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells ?
-
 ?
additional information Adenia digitata the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells ?
-
 ?
additional information Ricinus communis the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target ?
-
 ?
additional information Shigella dysenteriae the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target ?
-
 ?

Organism

Organism UniProt Comment Textmining
Adenia digitata
-
-
-
Corynebacterium diphtheriae
-
-
-
Ricinus communis
-
-
-
Shigella dysenteriae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Corynebacterium diphtheriae
-
commercial preparation
-
 Adenia digitata
-
seed
-
 Ricinus communis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells Corynebacterium diphtheriae ?
-
 ?
additional information the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells Adenia digitata ?
-
 ?
additional information the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target Ricinus communis ?
-
 ?
additional information the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target Shigella dysenteriae ?
-
 ?

Subunits

Subunits Comment Organism
dimer (alphabeta) structure Ricinus communis
dimer (alphabeta) structure Adenia digitata
pentamer StxB Shigella dysenteriae

Synonyms

Synonyms Comment Organism
diphtheria toxin
-
 Corynebacterium diphtheriae
modeccin
-
 Adenia digitata
ricin
-
 Ricinus communis
RNA N-glycosidase
-
 Ricinus communis
RNA N-glycosidase
-
 Corynebacterium diphtheriae
RNA N-glycosidase
-
 Shigella dysenteriae
RNA N-glycosidase
-
 Adenia digitata
Shiga toxin
-
 Shigella dysenteriae
Stx
-
 Shigella dysenteriae
StxB
-
 Shigella dysenteriae
type II ribosome-inactivating protein
-
 Ricinus communis
type II ribosome-inactivating protein
-
 Corynebacterium diphtheriae
type II ribosome-inactivating protein
-
 Shigella dysenteriae
type II ribosome-inactivating protein
-
 Adenia digitata

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Shigella dysenteriae