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Literature summary for 3.2.2.22 extracted from

  • Muething, J.; Meisen, I.; Bulau, P.; Langer, M.; Witthohn, K.; Lentzen, H.; Neumann, U.; Peter-Katalinic, J.
    Mistletoe lectin I is a sialic acid-specific lectin with strict preference to gangliosides and glycoproteins with terminal Neu5Ac alpha 2-6Gal beta 1-4GlcNAc residues (2004), Biochemistry, 43, 2996-3007.
    View publication on PubMed
Search for more literature for 3.2.2.22

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28478
-
 1 * 28478, ML-I subunit A + 1 * 28981, ML-I subunits B, sequence calculation Viscum album
28981
-
 1 * 28478, ML-I subunit A + 1 * 28981, ML-I subunits B, sequence calculation Viscum album
66000
-
 holoenzyme, native PAGE Viscum album

Organism

Organism UniProt Comment Textmining
Viscum album
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native ML-I from plant extract by ammonium sulfate fractionation, and affinity chromatography Viscum album

Reaction

Reaction Comment Organism Reaction ID
A4324 in 28S rRNA + H2O = deadenylated 28S rRNA + adenine substrate recogition via glycoprotein binding, overview Viscum album
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 target cell recognition and binding specificity for glycoproteins and gangliosides from different target cell types, detailed overview Viscum album

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ML-I is a sialic acid-specific lectin with strict preference to gangliosides and glycoproteins with terminal Neu5Ac alpha 2-6Gal beta 1-4GlcNAc residues, e.g. on human granulocytes or erythrocytes, structural features, overview Viscum album ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 28478, ML-I subunit A + 1 * 28981, ML-I subunits B, sequence calculation Viscum album

Synonyms

Synonyms Comment Organism
mistletoe lectin I
-
 Viscum album
ML-I
-
 Viscum album
rRNA N-glycosidase
-
 Viscum album
type II ribosome-inactivating protein
-
 Viscum album
VAA-I
-
 Viscum album
Viscum album agglutinin I
-
 Viscum album
viscumin
-
 Viscum album