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Literature summary for 3.2.2.21 extracted from
- Base excision repair enzymes protect abasic sites in duplex DNA from interstrand cross-links (2015), Biochemistry, 54, 1849-1857 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | P29372 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AAG | - |
Homo sapiens |
| AlkA | - |
Escherichia coli |
| MPG | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | alkyladenine DNA glycosylase protects an abasic site on one strand of a DNA duplex from cross-linking with an amine on the opposing strand by binding tightly to the abasic site and sequestering it | Escherichia coli |
| physiological function | alkyladenine DNA glycosylase protects an abasic site on one strand of a DNA duplex from cross-linking with an amine on the opposing strand by binding tightly to the abasic site and sequestering it. AAG protects an abasic site opposite T, the product of its canonical glycosylase reaction, by a factor of about 10fold | Homo sapiens |
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Release 2023.1 (January 2023)
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