Literature summary for 3.2.2.19 extracted from

Smith, S.J.; Towers, N.; Saldanha, J.W.; Shang, C.A.; Mahmood, S.R.; Taylor, W.R.; Mohun, T.J.
The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly (2016), Dev. Biol., 416, 373-388 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of structure	Xenopus laevis

Organism

Organism	UniProt	Comment	Textmining
Xenopus laevis	Q6AZR2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Xenopus laevis	-

Synonyms

Synonyms	Comment	Organism
ADP-ribosylhydrolase-like 1	-	Xenopus laevis
AdprHl1	-	Xenopus laevis

General Information

General Information	Comment	Organism
physiological function	the abundance of Adprhl1 protein in tadpole hearts is tightly controlled through a negative regulatory mechanism targeting the 5'-coding sequence of Xenopus adprhl1. Overexpression of full length Adprhl1 variants modified to escape such repression, also disrupts cardiac myofibrillogenesis. Disarrayed myofibrils persist that show extensive branching, with sarcomere division occurring at the actin-Z-disc boundary. Adprhl1-positive cells contain thin actin threads, connected to numerous circular branch points. Recombinant Adprhl1 can localize to stripes adjacent to the Z-disc	Xenopus laevis

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Release 2023.1 (January 2023)