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Literature summary for 3.2.2.15 extracted from

  • Ishchenko, A.; Sinitsyna, O.; Krysanova, Z.; Vasyunina, E.; Saparbaev, M.; Sidorkina, O.; Nevinsky, G.
    Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil-DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats (2003), Med. Sci. Monit., 9, 16-24.
    View publication on PubMed
Search for more literature for 3.2.2.15

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine-containing DNA + H2O Rattus norvegicus incision activity is increased with age above 12 months of the Wistar and OXYS rats, relation to content of free radicals, overview hypoxanthine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats and OXYS rats, the latter showing inherited overgeneration of free radicals
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Purification (Commentary)

Purification (Comment) Organism
partially, preparation of mitochondria from liver Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity at different ages of both rat races Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine-containing DNA + H2O incision activity is increased with age above 12 months of the Wistar and OXYS rats, relation to content of free radicals, overview Rattus norvegicus hypoxanthine + DNA
-
 ?
hypoxanthine-containing oligodeoxynucleotide + H2O synthetic mismatched substrate, hyopxanthine-removing, incision activity Rattus norvegicus hypoxanthine + oligodeoxynucleotide
-
 ?

Synonyms

Synonyms Comment Organism
deoxyribonucleic acid glycosylase
-
 Rattus norvegicus
DNA(hypoxanthine) glycohydrolase
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 Rattus norvegicus
hypoxanthine DNA glycosylase
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 Rattus norvegicus
hypoxanthine-DNA glycosylase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus