Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.96 extracted from

  • Sjoegren, J.; Struwe, W.B.; Cosgrave, E.F.; Rudd, P.M.; Stervander, M.; Allhorn, M.; Hollands, A.; Nizet, V.; Collin, M.
    EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and alpha1-acid glycoprotein (2013), Biochem. J., 455, 107-118.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.96

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 pLysS cells Streptococcus pyogenes

Protein Variants

Protein Variants Comment Organism
E186L inactive Streptococcus pyogenes

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes T1WGN1 serotype M49
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose 4B column chromatography Streptococcus pyogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with N-glycosylated macroglobulin, N-glycosylated ovalbumin, N-glycosylated lactoferrin, N-glycosylated RNase B, and N-glycosylated fetuin Streptococcus pyogenes ?
-
 ?
N-glycosylated immunglobuline G + H2O the enzyme hydrolyses the N-linked glycan on the heavy chain of immunglobuline G Streptococcus pyogenes ?
-
 ?
N-glycosylated orosomucoid + H2O the enzyme cleaves only biantennary and sialylated structures of orosomucoid Streptococcus pyogenes ?
-
 ?

Synonyms

Synonyms Comment Organism
endo-beta-N-acetylglucosaminidase
-
 Streptococcus pyogenes
EndoS2
-
 Streptococcus pyogenes