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Literature summary for 3.2.1.96 extracted from

  • Chantret, I.; Fasseu, M.; Zaoui, K.; Le Bizec, C.; Yaye, H.S.; Dupre, T.; Moore, S.E.
    Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells (2010), PLoS ONE, 5, e11734.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae png1DELTA cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
endo-beta-N-acetylglucosaminidase
-
 Homo sapiens
Engase1p
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction Engase1p down regulation slows down free oligosaccharides bearing the di-N-acetylchitobiose to free oligosaccharides bearing a single N-acetylglucosamine conversion in Hep-G2 cells Homo sapiens
physiological function the enzyme (Engase1p)is necessary for efficient clearance of cytosolic free oligosaccharides into lysosomes. Engase1p trimming of free oligosaccharides bearing the di-N-acetylchitobiose is required for normal free oligosaccharides trafficking in HepG2 cells Homo sapiens