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Literature summary for 3.2.1.76 extracted from

  • Cheng, W.C.; Lin, C.K.; Li, H.Y.; Chang, Y.C.; Lu, S.J.; Chen, Y.S.; Chang, S.Y.
    A combinatorial approach towards the synthesis of non-hydrolysable triazole-iduronic acid hybrid inhibitors of human alpha-L-iduronidase discovery of enzyme stabilizers for the potential treatment of MPSI (2018), Chem. Commun. (Camb.), 54, 2647-2650 .
    View publication on PubMed
Search for more literature for 3.2.1.76

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R,3R,4S,5S,6R)-3,4,5-trihydroxy-7-[8-[4-([[6-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)hexanoyl]amino]methyl)-1H-1,2,3-triazol-1-yl]octyl]-7-azabicyclo[4.1.0]heptane-2-carboxylic acid
-
 Homo sapiens
(1R,2R,3R,4S,5S,6R)-7-(8-azidooctyl)-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptane-2-carboxylic acid irreversible inhibitor Homo sapiens
(1R,2S,3S,4R,5S,6R)-7-(8-azidooctyl)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol
-
 Homo sapiens
2-[(1E,3E,5E)-5-[1-(6-[[(1-[8-[(1R,2R,3R,4S,5S,6R)-2-carboxy-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptan-7-yl]octyl]-1H-1,2,3-triazol-4-yl)methyl]amino]-6-oxohexyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene]penta-1,3-dien-1-yl]-1,3,3-trimethyl-3H-indol-1-ium irreversible inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-methylumbelliferyl alpha-L-iduronide + H2O Homo sapiens
-
 4-methylumbelliferone + alpha-L-iduronic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35475
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl alpha-L-iduronide + H2O
-
 Homo sapiens 4-methylumbelliferone + alpha-L-iduronic acid
-
 ?

Synonyms

Synonyms Comment Organism
alpha-IDUA
-
 Homo sapiens
alpha-L-iduronidase
-
 Homo sapiens
glycosaminoglycan alpha-L-iduronohydrolase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0122
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,3S,4R,5S,6R)-7-(8-azidooctyl)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol
0.0406
-
 pH and temperature not specified in the publication Homo sapiens (1R,2R,3R,4S,5S,6R)-7-(8-azidooctyl)-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptane-2-carboxylic acid
0.0581
-
 pH and temperature not specified in the publication Homo sapiens 2-[(1E,3E,5E)-5-[1-(6-[[(1-[8-[(1R,2R,3R,4S,5S,6R)-2-carboxy-3,4,5-trihydroxy-7-azabicyclo[4.1.0]heptan-7-yl]octyl]-1H-1,2,3-triazol-4-yl)methyl]amino]-6-oxohexyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene]penta-1,3-dien-1-yl]-1,3,3-trimethyl-3H-indol-1-ium
0.0651
-
 pH and temperature not specified in the publication Homo sapiens (1R,2R,3R,4S,5S,6R)-3,4,5-trihydroxy-7-[8-[4-([[6-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)hexanoyl]amino]methyl)-1H-1,2,3-triazol-1-yl]octyl]-7-azabicyclo[4.1.0]heptane-2-carboxylic acid