Literature summary for 3.2.1.63 extracted from

Ashida, H.; Miyake, A.; Kiyohara, M.; Wada, J.; Yoshida, E.; Kumagai, H.; Katayama, T.; Yamamoto, K.
Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates (2009), Glycobiology, 19, 1010-1017.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene afcA, expression in Escherichia coli and in enzyme-deficient Bifidobacterium longum strain 105-A which renders the transformant able to utilize 2'-fucosyllactose as the sole carbon source	Bifidobacterium bifidum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2'-fucosyllactose + H2O	Bifidobacterium bifidum	-	L-fucose + lactose	-	?

Organism

Organism	UniProt	Comment	Textmining
Bifidobacterium bifidum	-	strain JCM1254, gene afcA	-
no activity in Bifidobacterium longum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2'-fucosyllactose + H2O	-	Bifidobacterium bifidum	L-fucose + lactose	-	?

Synonyms

Synonyms	Comment	Organism
AfcA	-	Bifidobacterium bifidum
More	AfcA, an inverting glycosidase, belongs to the glycoside hydrolase family GH95	Bifidobacterium bifidum

General Information

General Information	Comment	Organism
physiological function	AfcA plays essential role in degrading alpha1,2-fucosylated milk oligosaccharides and also glycoconjugates, in the gastrointestinal tracts of the host	Bifidobacterium bifidum

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Release 2023.1 (January 2023)