Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.52 extracted from

  • Shen, S.; Chen, W.; Dong, L.; Yang, Q.; Lu, H.; Zhang, J.
    Design and synthesis of naphthalimide group-bearing thioglycosides as novel beta-N-acetylhexosaminidases inhibitors (2018), J. Enzyme Inhib. Med. Chem., 33, 445-452 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.52

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris GS115 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2''-[azanediyldi(ethane-2,1-diyl)]di(1H-benzo[de]isoquinoline-1,3(2H)-dione) M-31850 Homo sapiens
2-(2-([(4-methoxyphenyl)methyl]amino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-(2-([(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethyl]-1H-benzo[de]isoquinoline-isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[2-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[2-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[2-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[2-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[3-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[3-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[3-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[3-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[4-[(2-acetamido-beta-D-glucopyranosyl)thio]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[4-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[4-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[4-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[4-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
2-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
-
 Homo sapiens
iminocyclitol
-
 Homo sapiens
NAG-thiazoline
-
 Homo sapiens
nagstatin
-
 Homo sapiens
naphthalimide
-
 Homo sapiens
PUGNAc
-
 Homo sapiens
pyrimethamine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His-Trap column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
-
 Homo sapiens 4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
Hex
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00091
-
 2-[2-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione at pH 4.0 and 30°C Homo sapiens
0.03042
-
 2-[3-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione at pH 4.0 and 30°C Homo sapiens