Literature summary for 3.2.1.52 extracted from

Hogenkamp, D.G.; Arakane, Y.; Kramer, K.J.; Muthukrishnan, S.; Beeman, R.W.
Characterization and expression of the beta-N-acetylhexosaminidase gene family of Tribolium castaneum (2008), Insect Biochem. Mol. Biol., 38, 478-489.

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Application

Application	Comment	Organism
additional information	FDL may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development	Tribolium castaneum
additional information	NAG1 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development	Tribolium castaneum
additional information	NAG2 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development	Tribolium castaneum
additional information	NAG3 may have a role in N-glycan processing in addition to its apparent role in cuticular chitin turnover during insect development	Tribolium castaneum

Cloned(Commentary)

Cloned (Comment)	Organism
full-length cDNA cloned into the pCRs4-TOPOs vector	Tribolium castaneum

Inhibitors

Inhibitors	Comment	Organism	Structure
dsRNA	mediates transcript depletion. Knockdown of transcripts results in phenotypes similar to those of NAG1 dsRNA-treated insects, but the effects are somewhat variable and less severe; mediates transcript depletion. Knockdown of transcripts results in phenotypes similar to those of NAG1 dsRNA-treated insects, but the effects are somewhat variable and less severe; mediates transcript depletion. Knockdown of transcripts results in phenotypes similar to those of NAG1 dsRNA-treated insects, but the effects are somewhat variable and less severe; mediates transcript depletion, NAG1 dsRNA is most effective in interrupting all three types of molts: larval-larval, larval-pupal, and pupal-adult, treated insects die after failing to completely shed their old cuticles	Tribolium castaneum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
67300	-	sequence analysis	Tribolium castaneum
67400	-	sequence analysis	Tribolium castaneum
67500	-	sequence analysis	Tribolium castaneum
72600	-	sequence analysis	Tribolium castaneum

Organism

Organism	UniProt	Comment	Textmining
Tribolium castaneum	A5YVX3	GA-1 strain	-
Tribolium castaneum	A5YVX4	GA-1 strain	-
Tribolium castaneum	A5YVX5	GA-1 strain	-
Tribolium castaneum	A5YVX6	GA-1 strain	-
Tribolium castaneum GA-1	A5YVX3	GA-1 strain	-
Tribolium castaneum GA-1	A5YVX4	GA-1 strain	-
Tribolium castaneum GA-1	A5YVX5	GA-1 strain	-
Tribolium castaneum GA-1	A5YVX6	GA-1 strain	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	FDL is expressed in midgut, but its expression in the carcass is approximately triple that in the midgut	Tribolium castaneum	-
additional information	NAG1 transcripts are the most abundant, particularly at the late pupal stage. Transcript levels of NAG1 are comparable in both the midgut and carcass	Tribolium castaneum	-
additional information	NAG2 is expressed at far higher levels in the midgut than in the carcass	Tribolium castaneum	-
additional information	NAG3 transcripts are the least abundant, even at their peak levels in the late larval stages. NAG3 is expressed at far higher levels in the midgut than in the carcass	Tribolium castaneum	-

Synonyms

Synonyms	Comment	Organism
FDL	-	Tribolium castaneum
N-acetylglucosaminidase	-	Tribolium castaneum
NAG1	-	Tribolium castaneum
NAG2	-	Tribolium castaneum
Nag3	-	Tribolium castaneum

pI Value

Organism	Comment	pI Value Maximum	pI Value
Tribolium castaneum	-	-	5.2
Tribolium castaneum	-	-	5.5
Tribolium castaneum	-	-	5.6
Tribolium castaneum	-	-	6.6

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Release 2023.1 (January 2023)