Application | Comment | Organism |
---|---|---|
medicine | GlcNAcase may be an important factor in the formation of paucimannosidic core N-glycans in Drosophila S2 cells. It may be possible to express complex glycoproteins in engineered Drosophila S2 cells by suppressing GlcNAcase in the N-glycosylation pathway | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-acetamido-1,2-dideoxynojirimycin | GlcNAcase suppression improves the N-glycan patterns in S2 cells | Drosophila melanogaster | |
RNAi | mediates mRNA suppression in S2 cells. About 50% reduction of Glc-NAcase activity through RNAi-mediated suppression regardless of applied dsRNA amounts compared to the case of original human erythropoietin-expressing S2 cells. GlcNAcase suppression decreases the amount of terminal Man available | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Drosophila melanogaster | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
S2 cell | transfected with human erythropoietin | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl beta-N-acetyl-D-glucosaminide + H2O | - |
Drosophila melanogaster | 4-nitrophenol + N-acetyl-beta-D-glucosamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-N-acetylglucosaminidase | - |
Drosophila melanogaster |
GlcNAcase | - |
Drosophila melanogaster |