Literature summary for 3.2.1.52 extracted from

Miller, A.L.; Norton, V.; Robertson, R.; Jenks, M.; Yeh, R.Y.; Wright, D.
Light and heavy lysosomes: characterization of N-acetyl-beta-D-hexosaminidase isolatad from normal and I-cell disease lymphoblasts (1993), Glycobiology, 3, 313-318.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-beta-D-hexosaminides + H2O	Homo sapiens	-	N-acetyl-D-hexosamines	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with I-cell disease and healthy persons	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	carbohydrate modification	Homo sapiens
glycoprotein	carbohydrate units on enzymes isolated from I-cell or Pseudo-Hurler patients show modification to hybrid- or complex-type oligosaccharide	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphoblast	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0024	0.01	light lysosomal fraction, I-cell	Homo sapiens
0.0032	0.008	light lysosomal fraction, normal	Homo sapiens
0.0033	0.0066	light lysosomal fraction, Pseudo-Hurler	Homo sapiens
0.0051	0.0079	heavy lysosomal fraction, I-cell	Homo sapiens
0.0061	0.0075	heavy lysosomal fraction, Pseudo-Hurler	Homo sapiens
0.0061	0.0211	heavy lysosomal fraction, normal	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-galactopyranoside + H2O	-	Homo sapiens	4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-galactopyranoside	-	?
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O	-	Homo sapiens	4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside	-	?
N-acetyl-beta-D-hexosaminides + H2O	-	Homo sapiens	N-acetyl-D-hexosamines	-	?

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Release 2023.1 (January 2023)