Application | Comment | Organism |
---|---|---|
medicine | globoid cell leukodystrophy, GLD or Krabbe disease, is caused by loss-of-fuction mutations in the GALC gene, injection of GALC improves the survival of the mouse model of GLD | Mus musculus |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-galactosyl-N-acylsphingosine + H2O | Mus musculus | - |
D-galactose + N-acylsphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
twitcher mouse | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000008 | - |
GALC enzyme activity in the posterior part of the brain of single intracerebroventricular-GALC injected mice | Mus musculus |
0.0000087 | - |
GALC enzyme activity in the anterior part of the brain of single intracerebroventricular-GALC injected mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-galactosyl-N-acylsphingosine + H2O | - |
Mus musculus | D-galactose + N-acylsphingosine | - |
? | |
psychosine + H2O | galactosylsphingosine | Mus musculus | D-galactose + sphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
galactocerebrosidase | - |
Mus musculus |
Galactosylceramidase | - |
Mus musculus |
GALC | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
GALC substrate cleavage assay | Mus musculus |