Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-deoxynojirimycin | - |
Homo sapiens | |
4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide | - |
Homo sapiens | |
N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | GBA | Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucosylceramide + H2O | Homo sapiens | - |
beta-D-glucose + ceramide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | non-lysosomal GBA2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-beta-D-glucoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-glucose | - |
? | |
glucosylceramide + H2O | - |
Homo sapiens | beta-D-glucose + ceramide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ceredase | commercial preparation | Homo sapiens |
Cerezyme | commercial preparation | Homo sapiens |
GBA | lysosomal glucocerebrosidase | Homo sapiens |
GBA2 | non-lysosomal glucoceramidase | Homo sapiens |
glucocerebrosidase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
non-lysosomal GBA2 | Homo sapiens | N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin | |
0.000075 | - |
non-lysosomal GBA2 | Homo sapiens | 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide | |
0.00035 | - |
lysosomal GBA | Homo sapiens | N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin | |
0.00165 | - |
lysosomal GBA | Homo sapiens | 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide | |
0.0288 | - |
non-lysosomal GBA2 | Homo sapiens | 1-deoxynojirimycin | |
0.506 | - |
lysosomal GBA | Homo sapiens | 1-deoxynojirimycin |