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Literature summary for 3.2.1.45 extracted from

  • Scherpenzeel, M.; van den Berg, R.; Donker-Koopman, W.; Liskamp, R.; Aerts, J.; Overkleeft, H.; Pieters, R.
    Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase (2010), Bioorg. Med. Chem., 18, 267-273.
    View publication on PubMed
Search for more literature for 3.2.1.45

Inhibitors

Inhibitors Comment Organism Structure
1-deoxynojirimycin
-
 Homo sapiens
4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
-
 Homo sapiens
N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome GBA Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucosylceramide + H2O Homo sapiens
-
 beta-D-glucose + ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta non-lysosomal GBA2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucoside + H2O
-
 Homo sapiens 4-methylumbelliferone + beta-D-glucose
-
 ?
glucosylceramide + H2O
-
 Homo sapiens beta-D-glucose + ceramide
-
 ?

Synonyms

Synonyms Comment Organism
Ceredase commercial preparation Homo sapiens
Cerezyme commercial preparation Homo sapiens
GBA lysosomal glucocerebrosidase Homo sapiens
GBA2 non-lysosomal glucoceramidase Homo sapiens
glucocerebrosidase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
 non-lysosomal GBA2 Homo sapiens N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
0.000075
-
 non-lysosomal GBA2 Homo sapiens 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
0.00035
-
 lysosomal GBA Homo sapiens N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
0.00165
-
 lysosomal GBA Homo sapiens 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
0.0288
-
 non-lysosomal GBA2 Homo sapiens 1-deoxynojirimycin
0.506
-
 lysosomal GBA Homo sapiens 1-deoxynojirimycin