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Literature summary for 3.2.1.45 extracted from

  • Chang, H.H.; Asano, N.; Ishii, S.; Ichikawa, Y.; Fan, J.Q.
    Hydrophilic iminosugar active-site-specific chaperones increase residual glucocerebrosidase activity in fibroblasts from Gaucher patients (2006), FEBS J., 273, 4082-4092.
    View publication on PubMed
Search for more literature for 3.2.1.45

Protein Variants

Protein Variants Comment Organism
N370S Gaucher disease-causing mutation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,4-dideoxy-1,4-imino-D-arabinitol
-
 Homo sapiens
1,5-dideoxy-1,5-iminoxylitol potent inhibitor Homo sapiens
1-deoxynojirimycin
-
 Homo sapiens
2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine
-
 Homo sapiens
calystegine A3 potent inhibitor Homo sapiens
calystegine A5
-
 Homo sapiens
calystegine B1 potent inhibitor Homo sapiens
calystegine B2 potent inhibitor Homo sapiens
calystegine B3
-
 Homo sapiens
calystegine B4
-
 Homo sapiens
calystegine C1 potent inhibitor Homo sapiens
castanospermine
-
 Homo sapiens
isofagomine potent inhibitor Homo sapiens
N-butyl-1-deoxynojirimycin
-
 Homo sapiens
N-butylisofagomine
-
 Homo sapiens
N-dodecyl-1-deoxynojirimycin potent inhibitor Homo sapiens
N-methylcalystegine B2
-
 Homo sapiens
nojirimycin bisulfite
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Homo sapiens methylumbelliferone + beta-D-glucose
-
 ?

Synonyms

Synonyms Comment Organism
Ceredase
-
 Homo sapiens
Gcase
-
 Homo sapiens
glucocerebrosidase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens isofagomine
0.00005
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens N-dodecyl-1-deoxynojirimycin
0.001
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine B2
0.0023
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens 1,5-dideoxy-1,5-iminoxylitol
0.0025
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine B1
0.0025
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine C1
0.0031
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine A3
0.019
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens castanospermine
0.028
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens nojirimycin bisulfite
0.031
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine A5
0.044
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens N-butyl-isofagomine
0.076
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine B3
0.082
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens calystegine B4
0.16
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens 1,4-dideoxy-1,4-imino-D-arabinitol
0.24
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens 1-deoxynojirimycin
0.27
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-glucopyranoside as substrate Homo sapiens N-butyl-1-deoxynojirimycin
0.28
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine
0.32
-
 in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate Homo sapiens N-methyl-calystegine B2