Literature summary for 3.2.1.39 extracted from

Dong, W.; Huang, J.; Li, Y.; Tan, Y.; Shen, Z.; Song, Y.; Wang, D.; Xiao, S.; Chen, H.; Fu, Z.F.; Peng, G.
Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis (2015), Sci. Rep., 5, 15073.

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Application

Application	Comment	Organism
medicine	the enzyme is an immunostimulatory antigen. Glu-176, a conserved catalytic residue in GH16 endo-beta-1,3-glucanases, is essential for Rv0315 to induce immunological responses	Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of Rv0315 at 1.70 A resolution. Rv0315 is an inactive beta-1,3-glucanase of the glycoside hydrolase 16 (GH16) family. Rv0315 has a large open groove, and this particular topology cannot bind oligosaccharide chains in solution, thus explaining the lack of detectable hydrolytic activity towards its substrate	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	O07242	-	-
Mycobacterium tuberculosis H37Rv	O07242	-	-

Synonyms

Synonyms	Comment	Organism
Rv0315	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)