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Literature summary for 3.2.1.36 extracted from

  • Ozegowski, J.H.; Gunther, E.; Reichardt, W.
    Purification and characterization of hyaluronidase from Streptococcus agalactiae (1994), Zentralbl. Bakteriol., 280, 497-506.
    View publication on PubMed
Search for more literature for 3.2.1.36

Inhibitors

Inhibitors Comment Organism Structure
Al3+ strong inhibition at 10 mM Streptococcus agalactiae
Cu2+ nearly complete inhibition at 10 mM Streptococcus agalactiae
Fe2+ complete inhibition at 10 mM Streptococcus agalactiae
Mn2+ strong inhibition at 10 mM Streptococcus agalactiae
polymer from gentisic acid with formaldehyde, nearly complete inhibition at 0.01 mg/ml Streptococcus agalactiae
polymer from hydroxysulfonic acid with formaldehyde, nearly complete inhibition at 0.01 mg/ml Streptococcus agalactiae
Zn2+ strong inhibition at 10 mM Streptococcus agalactiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 hyaluronoic acid value in mg/ml Streptococcus agalactiae
additional information
-
 hyaluronoic acid 0.08 mg/ml Streptococcus agalactiae

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted from cell culture Streptococcus agalactiae
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 4fold increased activity at 10 mM Streptococcus agalactiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
116000
-
 SDS-PAGE Streptococcus agalactiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronic acid + H2O Streptococcus agalactiae major pathogenic factor of serological group B streptococci ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
highly purified, chromatography steps Streptococcus agalactiae

Source Tissue

Source Tissue Comment Organism Textmining
cell culture serological group B strains, 3402 type II and 4755 Streptococcus agalactiae
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity measured as turbidicity reducing units Streptococcus agalactiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chondroitin sulfate A + H2O low activity Streptococcus agalactiae oligosaccharides + ?
-
 ?
dermatan sulfate + H2O chondroitin sulfate B, low activity Streptococcus agalactiae ?
-
 ?
hyaluronic acid + H2O major pathogenic factor of serological group B streptococci Streptococcus agalactiae ?
-
 ?
hyaluronic acid + H2O
-
 Streptococcus agalactiae hyaluronic acid oligomers
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3
-
-
 Streptococcus agalactiae