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Literature summary for 3.2.1.35 extracted from

  • Buhren, B.A.; Schrumpf, H.; Hoff, N.P.; Boelke, E.; Hilton, S.; Gerber, P.A.
    Hyaluronidase from clinical applications to molecular and cellular mechanisms (2016), Eur. J. Med. Res., 21, 5.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine bovine hyaluronidase is an adjuvant for infiltration anesthesia. By degrading hyaluronan in the extracellular matrix, hyaluronidase increases membrane permeability, thereby rendering tissues more permeable to injected fluids. As a consequence, hyaluronidase reduces viscosity of hyaluronan which improves tissue diffusion and the resorption rate of excess fluids. Co-administration of hyaluronidase is a potential option to enhance the effectiveness of local anesthesia, increasing the analgesic efficacy with respect to the anesthetized area per time (e.g., subcutaneous and intramuscular injections). Hyaluronidase is used in ophthalmic surgery in combination with local anesthetics for peritubular, retrotubular or sub-Tenon's anesthesia and is established in other surgical disciplines, including dermatosurgery. Injection of hyaluronidase-based fillers in aesthetic dermatology Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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Synonyms

Synonyms Comment Organism
hyaluronidase
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Bos taurus