Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.35 extracted from

  • Wang, Z.; Guo, C.; Xu, Y.; Liu, G.; Lu, C.; Liu, Y.
    Two novel functions of hyaluronidase from Streptococcus agalactiae are enhanced intracellular survival and inhibition of proinflammatory cytokine expression (2014), Infect. Immun., 82, 2615-2625.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.35

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Streptococcus agalactiae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronan + 2 H2O Streptococcus agalactiae
-
 N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?
hyaluronan + 2 H2O Streptococcus agalactiae GD201008-001
-
 N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae
-
-
-
Streptococcus agalactiae GD201008-001
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronan + 2 H2O
-
 Streptococcus agalactiae N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?
hyaluronan + 2 H2O
-
 Streptococcus agalactiae GD201008-001 N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Synonyms

Synonyms Comment Organism
hyaluronidase
-
 Streptococcus agalactiae
HYL
-
 Streptococcus agalactiae
hylB
-
 Streptococcus agalactiae

General Information

General Information Comment Organism
malfunction enzyme deficiency reduces survival in macrophages compared to the wild type and stimulates a significantly higher release of proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha than the wild type in macrophages as well as in mice Streptococcus agalactiae
physiological function hyaluronidase has a strong influence on the intracellular survival of Streptococcus agalactiae and proinflammatory cytokine expression, suggesting that it plays a key role in pathogenicity Streptococcus agalactiae