Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.35 extracted from

  • Salmen, S.; Hoechstetter, J.; Kaesbauer, C.; Paper, D.H.; Bernhardt, G.; Buschauer, A.
    Sulphated oligosaccharides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae (2005), Planta Med., 71, 727-732.
    View publication on PubMed
Search for more literature for 3.2.1.35

Inhibitors

Inhibitors Comment Organism Structure
apigenin 52% inhibition at 1 mM and 10 mM Bos taurus
beta1,4-galacto-oligosaccharides partially sulfated and non-sulfated forms, especially tri-, tetra-, and pentasaccharides Apis mellifera
beta1,4-galacto-oligosaccharides partially sulfated and non-sulfated forms, especially tri-, tetra-, and pentasaccharides, IC50 values Bos taurus
kaempferol 36% inhibition at 1 mM Bos taurus
additional information inhibition curves, overview Bos taurus
partially sulfated neomycin the non-sulfated neomycin is not inhibitory Apis mellifera
partially sulfated neomycin the non-sulfated neomycin is not inhibitory Bos taurus
partially sulfated planteose the non-sulfated planteose is not inhibitory, IC50 is 0.008 mM Apis mellifera
partially sulfated planteose the non-sulfated planteose is not inhibitory, IC50 is 0.005 mM Bos taurus
partially sulfated verbascose 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.040 mM and 0.003 mM Apis mellifera
partially sulfated verbascose 2 forms, the non-sulfated verbascose is not inhibitory Bos taurus
sulfated 2-hydroxyphenyl monolactobioside IC50 is 0.025 mM Bos taurus
sulfated hydroquinone galactoside IC50 is 0.006 mM Apis mellifera
sulfated hydroquinone galactoside IC50 is 0.015 mM Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular venom Apis mellifera
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronic acid + H2O Bos taurus
-
 ?
-
 ?
hyaluronic acid + H2O Apis mellifera
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Apis mellifera
-
-
-
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from testis Bos taurus
-
testis commercial preparation Bos taurus
-
venom
-
 Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronic acid + H2O
-
 Bos taurus ?
-
 ?
hyaluronic acid + H2O
-
 Apis mellifera ?
-
 ?
hyaluronic acid + H2O from rooster comb Bos taurus ?
-
 ?
hyaluronic acid + H2O from rooster comb Apis mellifera ?
-
 ?

Synonyms

Synonyms Comment Organism
BTH
-
 Bos taurus
BVH
-
 Apis mellifera
hyaluronidase
-
 Bos taurus
hyaluronidase
-
 Apis mellifera

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus
37
-
 assay at Apis mellifera

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6
-
-
 Bos taurus
3.6
-
-
 Apis mellifera

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005
-
 the non-sulfated planteose is not inhibitory, IC50 is 0.005 mM Bos taurus partially sulfated planteose
0.006
-
 IC50 is 0.006 mM Apis mellifera sulfated hydroquinone galactoside
0.008
-
 the non-sulfated planteose is not inhibitory, IC50 is 0.008 mM Apis mellifera partially sulfated planteose
0.015
-
 IC50 is 0.015 mM Bos taurus sulfated hydroquinone galactoside
0.025
-
 IC50 is 0.025 mM Bos taurus sulfated 2-hydroxyphenyl monolactobioside
0.04
-
 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.040 mM and 0.003 mM Apis mellifera partially sulfated verbascose