Inhibitors | Comment | Organism | Structure |
---|---|---|---|
curcumin | IC50 is 0.057 mM | Naja naja | |
indomethacin | IC50 is 0.086 mM | Naja naja | |
Tannic acid | IC50 is 0.070 mM | Naja naja |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | venom | Naja naja | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
1 * 52000, isozyme NNH2, SDS-PAGE | Naja naja |
54000 | - |
isozyme NNH2, gel filtration | Naja naja |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | Naja naja | human skin sections | hyaluronan oligomers | - |
? | |
additional information | Naja naja | isozyme NNH2 is nontoxic, but indirectly potentiates the hemorrhagic activity of hemorrhagic complex-I | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Naja naja | - |
isozyme NNH2 | - |
Purification (Comment) | Organism |
---|---|
native isozyme NNH2 26fold to homogeneity from venom by successive gel filtration and ion exchange chromatography | Naja naja |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Naja naja | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
isozyme NNH2 | Naja naja |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | human skin sections | Naja naja | hyaluronan oligomers | - |
? | |
hyaluronan + H2O | isozyme NNH2 shows endoglycosidase activity, absolute specific for in vitro, substrate from human skin | Naja naja | hyaluronan oligomers | - |
? | |
additional information | isozyme NNH2 is nontoxic, but indirectly potentiates the hemorrhagic activity of hemorrhagic complex-I | Naja naja | ? | - |
? | |
additional information | no activity with chondroitin sulfates, heparin, and different chitosans | Naja naja | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 52000, isozyme NNH2, SDS-PAGE | Naja naja |
Synonyms | Comment | Organism |
---|---|---|
hyaluronidase | - |
Naja naja |
NNH2 | - |
Naja naja |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Naja naja | isoelectric focusing, isozyme NNH2 | - |
9.7 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.057 | - |
IC50 is 0.057 mM | Naja naja | curcumin | |
0.07 | - |
IC50 is 0.070 mM | Naja naja | Tannic acid | |
0.086 | - |
IC50 is 0.086 mM | Naja naja | indomethacin |