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Literature summary for 3.2.1.31 extracted from

  • Mabkhot, Y.N.; Barakat, A.; Yousuf, S.; Choudhary, M.I.; Frey, W.; Ben Hadda, T.; Mubarak, M.S.
    Substituted thieno[2,3-b]thiophenes and related congeners: synthesis, beta-glucuronidase inhibition activity, crystal structure, and POM analyses (2014), Bioorg. Med. Chem., 22, 6715-6725.
    View publication on PubMed
Search for more literature for 3.2.1.31

Inhibitors

Inhibitors Comment Organism Structure
1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)bis(4,4,4-triethoxybut-2-en-1-one)
-
 Homo sapiens
D-saccharic acid 1,4-lactone
-
 Homo sapiens
additional information substituted thieno[2,3-b]thiophenes and related congeners, synthesis of compounds incorporating the thieno[2,3-b]thiophene moiety, beta-glucuronidase inhibition activity, cytotoxicity, crystal structure, and Petra/Osiris/Molinspiration analyses, overview. No activity with 1,1'-(3-phenyl-4-methylthieno[2,3-b]thiene-2,5-diyl)bis[3-(dimethylamino)prop-2-en-1-one] and diethyl-4,4'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-dicarbonyl)bis(1-phenyl-1H-pyrazole-3-carboxylate) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-glucuronide + H2O
-
 Homo sapiens 4-nitrophenol + beta-D-glucuronate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
 pH not specified in the publication, 37°C Homo sapiens 1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)bis(4,4,4-triethoxybut-2-en-1-one)
0.0458
-
 pH not specified in the publication, 37°C Homo sapiens D-saccharic acid 1,4-lactone