Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-deoxy-L-altronojirimycin hydrochloride | 1000fold less effective than 1-deoxygalactonojirimycin | Homo sapiens | |
1-deoxygalactonojirimycin | binding to the enzyme protein is enthalpy-driven and stronger than binding of galactostatin bisulfite. Inhibitor fits to the active-site pocket and undergoes hydrogen bonding with residues comprising the active-site pocket including the catalytic ones | Homo sapiens | |
galactostatin bisulfite | inhibits in vitro, increases enzyme activity in cultured Fabry fibroblasts. Binding is less strong than binding of 1-deoxygalactonojirimycin, and interaction with enzyme protein is mainly enthalpie-driven but entropy-driven factors may be involved. Inhibitor fits to the active-site pocket and undergoes hydrogen bonding with residues comprising the active-site pocket including the catalytic ones | Homo sapiens | |
n-butyldeoxygalactonojirimycin | 2000fold less effective than 1-deoxygalactonojirimycin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P06280 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl alpha-D-galactoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + alpha-D-galactose | - |
? |