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Literature summary for 3.2.1.22 extracted from

  • Rietra, P.J.G.M.; Tager, J.M.; Borst, P.
    Detection and properties of an acid alpha-galactosidase (ceramidetrihexosidase) in normal human urine (1972), Biochim. Biophys. Acta, 279, 436-445.
    View publication on PubMed
Search for more literature for 3.2.1.22

Inhibitors

Inhibitors Comment Organism Structure
D-myo-inositol weak competitive inhibitor Homo sapiens
galactose weak competitive inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.7 9.3 p-nitrophenyl-alpha-galactoside
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O Homo sapiens
-
 lactosyl-N-acylsphingosine + D-galactose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
5°C, at least 3 days, dialysed (NH4)2SO4 precipitates, at least 1 month Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O
-
 Homo sapiens lactosyl-N-acylsphingosine + D-galactose
-
 ?
additional information some evidence for a single enzyme with ceramide trihexosidase activity and 4-methylumbelliferyl-alpha-galactosidase activity Homo sapiens ?
-
 ?
p-nitrophenyl-alpha-galactoside + H2O
-
 Homo sapiens p-nitrophenol + galactose
-
 ?

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.4
-
 above no activity Homo sapiens